Understanding how nuclear shape is regulated in cells
Official title: Mechanisms of nuclear morphology regulation
Funded at University of Wyoming · NIH-11074098 · Data updated 2026-11-12
This study is looking at how the size and shape of cell nuclei can change in cancer, using tiny worms and human stem cells to find out how these changes might help us understand and treat cancer better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wyoming NIH-funded |
| Lab location | 1 site (Laramie, United States) |
| Project start | January 1, 2020 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $351,135 |
| NIH project number | 5R35GM134885-07 |
| Project ID | NIH-11074098 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancer or those at risk of developing cancer, particularly those interested in the biological mechanisms of their condition.
✕Less likely to help
Patients with non-cancerous conditions or those not interested in the biological aspects of cancer may not benefit from this research.
What this research studies
This research investigates the mechanisms that control the size and shape of the nucleus in cells, particularly in the context of cancer. By using various experimental approaches, including studies in model organisms like C. elegans and human stem cells, the research aims to uncover how changes in nuclear morphology can affect cancer diagnosis and progression. The team will explore both normal and stress conditions to understand the underlying biological processes. This work could lead to new insights into cancer biology and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could improve cancer diagnosis and treatment by providing new insights into the role of nuclear morphology in cancer progression.
How similar studies have gone: While the specific focus on nuclear morphology in cancer is a novel approach, related studies have shown success in understanding cellular mechanisms in cancer biology.
Where this research is happening
-
University of Wyoming
Laramie, United States Active
Researchers
- Principal investigator: Levy, Daniel Leon — University of Wyoming
- Study coordinator: Levy, Daniel Leon
Related research
Other NIH-funded projects on the same topics.
-
Studying how aging and Alzheimer’s affect the front part of the brain using real-time imaging and computer models
Researchers will combine live brain imaging in animals with computer simulations to understand how aging and Alzheimer’s disease change the prefrontal cortex and relate to memory and thinking problems.
-
Remote AI-guided speech cues to help people with Parkinson’s speak more clearly
A remote AI-based tool uses a web camera to give personalized speech cues to adults with Parkinson’s to improve how clearly they talk.
-
Unlocking biased GPCR signaling to guide safer, smarter drugs
A research program from the University of Wyoming aims to understand how different beta-arrestin proteins shape GPCR signaling to help design drugs with better therapeutic effects and fewer side effects.
-
Ribosomal proteins and pseudogenes in stress-affected neurons
This project looks at how stress changes the proteins that make up ribosomes in brain cells, which could reveal new ways stress affects nervous system health.
-
Impact of early overfeeding on brain hunger neurons and energy balance
This grant looks at how early-life overnutrition may change brain circuits that control hunger and energy use, with potential implications for preventing obesity-related diseases.
-
Exercise timing to reset the brain’s body clock in breast cancer care
A study tests whether exercising at specific times can reset the brain’s circadian clock and potentially improve well-being for people coping with breast cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.