Understanding how new proteins in the pancreas trigger Type 1 diabetes
Discovery and Roles of In Situ Islet Neoantigens in Human Type 1 Diabetes
This study is looking into why the immune system attacks insulin-producing cells in people at risk for Type 1 diabetes, hoping to find specific proteins that could help us understand the disease better and lead to new ways to prevent or treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10996095 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind Type 1 diabetes (T1D), focusing on how the immune system mistakenly attacks pancreatic beta-cells. The team aims to identify specific proteins, known as neoantigens, that may trigger this autoimmune response. By analyzing pancreatic islets from individuals at risk for T1D, they will use advanced techniques to discover and validate these neoantigens. This could lead to a better understanding of the disease and potential new strategies for prevention or treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Type 1 diabetes or those who have recently been diagnosed.
Not a fit: Patients with Type 2 diabetes or other unrelated autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing or treating Type 1 diabetes by targeting the specific proteins involved in the disease.
How similar studies have performed: Other research has shown promise in identifying neoantigens in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Mathews, Clayton E — University of Florida
- Study coordinator: Mathews, Clayton E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.