Understanding how new proteins in the pancreas trigger Type 1 diabetes
Official title: Discovery and Roles of In Situ Islet Neoantigens in Human Type 1 Diabetes
Funded at University of Florida · NIH-10996095 · Data updated 2026-11-12
This study is looking into why the immune system attacks insulin-producing cells in people at risk for Type 1 diabetes, hoping to find specific proteins that could help us understand the disease better and lead to new ways to prevent or treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | February 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $691,406 |
| NIH project number | 5R01DK135081-03 |
| Project ID | NIH-10996095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Type 1 diabetes or those who have recently been diagnosed.
✕Less likely to help
Patients with Type 2 diabetes or other unrelated autoimmune conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms behind Type 1 diabetes (T1D), focusing on how the immune system mistakenly attacks pancreatic beta-cells. The team aims to identify specific proteins, known as neoantigens, that may trigger this autoimmune response. By analyzing pancreatic islets from individuals at risk for T1D, they will use advanced techniques to discover and validate these neoantigens. This could lead to a better understanding of the disease and potential new strategies for prevention or treatment.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing or treating Type 1 diabetes by targeting the specific proteins involved in the disease.
How similar studies have gone: Other research has shown promise in identifying neoantigens in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Mathews, Clayton E — University of Florida
- Study coordinator: Mathews, Clayton E
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.