Understanding how neutrophils behave in cancer
A blueprint for neutrophil heterogeneity and reprogramming in cancer
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-10472807
This study is looking at how certain immune cells called neutrophils behave in cancer, hoping to find ways to develop better treatments that can stop the bad neutrophils that help tumors grow while keeping the good ones that fight infections, which could help patients with cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10472807 on ClinicalTrials.gov |
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in cancer progression. It aims to differentiate between tumor-associated neutrophils and normal neutrophils to understand their distinct functions in the tumor microenvironment. By exploring the genetic and epigenetic changes in these cells, the research seeks to identify potential targets for new cancer therapies that can selectively inhibit tumor-promoting neutrophils while preserving the immune system's ability to fight infections. Patients may benefit from insights that could lead to more effective and targeted cancer treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with various types of cancer who may benefit from innovative immunotherapy approaches.
Not a fit: Patients with non-cancerous conditions or those not affected by neutrophil-related issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target harmful neutrophils in cancer without compromising the immune response to infections.
How similar studies have performed: Other research has shown promise in targeting immune cells for cancer therapy, suggesting that this approach could yield significant advancements.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIN, CHENGCHENG — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: JIN, CHENGCHENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections, bacteria infection, bacterial disease, Cancers, neoplasm/cancer