Understanding how neurons distinguish themselves from others
How do neurons recognize self from non-self?
This study is looking at how brain cells recognize themselves and keep from mixing up with each other, which is really important for how our brains work, and it could help us understand conditions like autism and schizophrenia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11062755 on NIH RePORTER |
What this research studies
This research investigates how neurons in the brain recognize themselves and avoid overlapping with other neurons, a process crucial for proper brain function. It focuses on the role of Protocadherin (Pcdh) proteins, which help neurons identify themselves through unique 'barcodes' on their surfaces. By exploring the mechanisms behind the production of diverse Pcdh proteins, the research aims to uncover fundamental insights into neuronal behavior and its implications for neurological disorders like autism and schizophrenia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related neurological conditions.
Not a fit: Patients with neurological disorders unrelated to self-recognition mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for neurological disorders associated with neuronal self-recognition, such as autism spectrum disorder.
How similar studies have performed: While the specific focus on Pcdh protein diversity is novel, related research has shown promise in understanding neuronal behavior and its implications for brain disorders.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Canzio, Daniele — University of California, San Francisco
- Study coordinator: Canzio, Daniele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.