Understanding how nerves can be guided to heal after injury to improve voice function
Mechanisms of axon guidance in laryngeal reinnervation following injury of the recurrent laryngeal nerve
This study is looking at how to help nerves heal better after injury, especially the one that helps you speak, so that people with voice problems can regain their normal voice.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10663855 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind nerve regeneration, specifically focusing on the recurrent laryngeal nerve, which is crucial for voice production. It aims to identify the molecular cues that guide nerve fibers to reconnect properly after injury, which can lead to vocal fold paralysis and severe voice dysfunction. By manipulating these guidance cues, the researchers hope to restore normal voice function in patients who have suffered from nerve injuries. The study involves both laboratory experiments and potential clinical applications to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced recurrent laryngeal nerve injuries resulting in voice dysfunction.
Not a fit: Patients with voice disorders not related to recurrent laryngeal nerve injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore normal voice function for patients with recurrent laryngeal nerve injuries.
How similar studies have performed: While there has been some research on nerve regeneration, the specific approach of manipulating guidance cues for laryngeal nerve recovery is relatively novel and has not been extensively tested.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Pitman, Michael — Columbia University Health Sciences
- Study coordinator: Pitman, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.