Understanding how nerve cells find their targets during development
Regulating axon guidance through local translation at adhesions
This study looks at how growing nerve cells find their way to connect with the right partners in the nervous system, focusing on how outside signals help them do this by making proteins at specific spots, which is important for their growth and connections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11066511 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which developing nerve cells, specifically their growth cones, navigate to connect with the correct targets in the nervous system. It focuses on how external signals influence the internal processes of these cells, particularly through local translation of proteins at specific adhesion sites called point contacts. By examining these processes, the research aims to uncover how these localized translations affect axon growth and guidance, which are crucial for proper neuronal connectivity. This work could lead to a better understanding of the fundamental processes that govern nerve cell development and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting neuronal connectivity or development, such as congenital neurological disorders.
Not a fit: Patients with fully developed nervous systems and no neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into nerve cell development, potentially informing treatments for neurological disorders related to axon guidance.
How similar studies have performed: While the specific approach of examining local translation at point contacts is novel, similar studies have shown promise in understanding axon guidance and neuronal connectivity.
Where this research is happening
Columbia, United States
- University of South Carolina at Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Welshhans, Kristy — University of South Carolina at Columbia
- Study coordinator: Welshhans, Kristy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.