Understanding how mutations help maintain balance in aging tissues
Defining the role of mutational burden in sustaining normal homeostasis during aging
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-10647740
This study is looking at how changes in our cells might actually help keep our skin and intestines healthy as we get older, and it's for anyone interested in understanding how our bodies handle these changes over time.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10647740 on ClinicalTrials.gov |
What this research studies
This research investigates how mutations in cells might play a role in keeping tissues healthy as we age. The team is exploring the idea that while mutations are often linked to diseases like cancer, they may also help maintain normal function in aged tissues by promoting a balance between different cell types. By studying tissues such as skin and intestines, the researchers aim to uncover the mechanisms that allow both normal and mutant cells to coexist and support overall tissue health. This could lead to new insights into how our bodies manage cellular changes over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are generally healthy but may have underlying mutations in their tissues.
Not a fit: Patients with active cancer or severe chronic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new strategies for promoting healthy aging and preventing age-related diseases.
How similar studies have performed: Other research has suggested that mutations can have complex roles in tissue health, indicating that this approach may yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRECO, VALENTINA — YALE UNIVERSITY
- Study coordinator: GRECO, VALENTINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: neoplasm/cancer, Chronic Disease, chronic disorder, Disease, Disorder