Understanding how mutations affect aging in primates
Comparative analyses of somatic mutational processes in primates across lifespans
This study looks at how genetic changes happen as primates get older, including marmosets, macaques, baboons, and chimpanzees, to help us understand aging and related health issues that could also apply to humans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10937006 on NIH RePORTER |
What this research studies
This research investigates the patterns of genetic mutations that occur as primates age, focusing on various species including marmosets, macaques, baboons, and chimpanzees. By analyzing tissue samples from these animals, the study aims to uncover how these mutations contribute to aging and age-related diseases. The researchers will utilize advanced genome sequencing techniques to create detailed maps of somatic mutations across different tissues and ages. This work could provide insights into the biological processes that influence lifespan and health in both primates and humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those who may be affected by age-related diseases.
Not a fit: Patients with no interest in aging research or those who do not have age-related health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of aging and the development of interventions to promote healthier aging in humans.
How similar studies have performed: Previous research has shown promising results in understanding aging through genetic studies in other species, suggesting that this approach could yield valuable insights.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Sudmant, Peter Heshedahl — University of California Berkeley
- Study coordinator: Sudmant, Peter Heshedahl
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.