Understanding how mutations affect aging in primates
Official title: Comparative analyses of somatic mutational processes in primates across lifespans
Funded at University of California Berkeley · NIH-10937006 · Data updated 2026-11-12
This study looks at how genetic changes happen as primates get older, including marmosets, macaques, baboons, and chimpanzees, to help us understand aging and related health issues that could also apply to humans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $687,288 |
| NIH project number | 1R01AG087974-01 |
| Project ID | NIH-10937006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those who may be affected by age-related diseases.
✕Less likely to help
Patients with no interest in aging research or those who do not have age-related health concerns may not benefit from this research.
What this research studies
This research investigates the patterns of genetic mutations that occur as primates age, focusing on various species including marmosets, macaques, baboons, and chimpanzees. By analyzing tissue samples from these animals, the study aims to uncover how these mutations contribute to aging and age-related diseases. The researchers will utilize advanced genome sequencing techniques to create detailed maps of somatic mutations across different tissues and ages. This work could provide insights into the biological processes that influence lifespan and health in both primates and humans.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of aging and the development of interventions to promote healthier aging in humans.
How similar studies have gone: Previous research has shown promising results in understanding aging through genetic studies in other species, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Sudmant, Peter Heshedahl — University of California Berkeley
- Study coordinator: Sudmant, Peter Heshedahl
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.