Understanding how mRNA processing affects health and disease
Official title: Decode polyadenylation in health and disease
Funded at University of California-Irvine · NIH-11029104 · Data updated 2026-11-12
This study is looking at how changes in our genes can affect the way our body processes important messages called mRNA, which can play a role in diseases like cancer and genetic disorders, and it aims to help patients understand how their unique genetic traits might influence their health and treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $667,379 |
| NIH project number | 1R01CA297834-01 |
| Project ID | NIH-11029104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic disorders such as beta-thalassemia or various cancers that may be influenced by mRNA processing.
✕Less likely to help
Patients with conditions unrelated to mRNA processing or those not carrying relevant genetic variants may not benefit from this research.
What this research studies
This research investigates the process of cleavage and polyadenylation (CPA) of mRNA, which is crucial for gene expression and can influence various diseases, including cancer and genetic disorders. The study aims to understand how genetic variants at polyadenylation sites can affect mRNA processing and lead to different disease outcomes. By analyzing the regulatory factors involved in CPA, the research seeks to develop predictive models that can help identify how these processes are altered in various health conditions. Patients may benefit from insights into how their genetic makeup influences disease progression and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for diseases linked to mRNA processing abnormalities.
How similar studies have gone: Previous research has shown promising results in targeting mRNA processing mechanisms for therapeutic purposes, indicating potential for success in this area.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Shi, Yongsheng — University of California-Irvine
- Study coordinator: Shi, Yongsheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.