Understanding how mouse models relate to human benign prostate hyperplasia
Official title: Validating Mouse Models of Prostatic Hyperplasia
Funded at Endeavor Health Clinical Operations · NIH-11145116 · Data updated 2026-11-12
This study is looking at specially designed mice to help us learn more about benign prostatic hyperplasia (BPH) in people, so we can find better treatments for the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endeavor Health Clinical Operations NIH-funded |
| Lab location | 1 site (Evanston, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $388,010 |
| NIH project number | 5P20DK140417-02 |
| Project ID | NIH-11145116 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from benign prostatic hyperplasia or related urinary symptoms.
✕Less likely to help
Patients with prostate cancer or other unrelated urological conditions may not benefit from this research.
What this research studies
This research focuses on validating genetically engineered mouse models to better understand benign prostatic hyperplasia (BPH) in humans. The project aims to correlate transcriptomic data from these mouse models with existing human datasets to identify similarities and differences. By doing so, the researchers hope to improve the relevance of animal models in biomedical research, which is crucial for developing effective treatments for BPH. The work will involve collaboration among biologists and a bioinformatician to create a comprehensive reference database.
Why it matters
Potential benefit: If successful, this research could lead to more accurate animal models that enhance the development of effective treatments for benign prostatic hyperplasia.
How similar studies have gone: Previous research has shown that improving the relevance of animal models can significantly enhance the understanding and treatment of various diseases, making this approach promising.
Where this research is happening
-
Endeavor Health Clinical Operations
Evanston, United States Active
Researchers
- Principal investigator: Hayward, Simon W — Endeavor Health Clinical Operations
- Study coordinator: Hayward, Simon W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.