Understanding how monocytes affect the response to HIV vaccines
Official title: "Evaluating the role of monocytes in the development of an effective HIV vaccine response"
Funded at University of Rochester · NIH-10923492 · Data updated 2026-11-12
This study is looking at how certain immune cells called monocytes can help make HIV vaccines work better, and it's for anyone interested in improving future HIV vaccine options.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $85,864 |
| NIH project number | 1F32AI181619-01A1 |
| Project ID | NIH-10923492 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are at risk of HIV infection or those who have previously participated in HIV vaccine trials.
✕Less likely to help
Patients who are not at risk for HIV or those who have already been vaccinated against HIV may not benefit from this research.
What this research studies
This research investigates the role of monocytes, a type of immune cell, in enhancing the effectiveness of HIV vaccines. By analyzing gene expression changes in monocytes after vaccination and infection, the study aims to identify specific monocyte subpopulations that contribute to a stronger antibody response. The research will utilize advanced techniques like CITE-seq and mathematical modeling to characterize these immune responses, potentially leading to improved vaccine strategies. Patients may benefit from insights that could enhance future HIV vaccine development.
Why it matters
Potential benefit: If successful, this research could lead to more effective HIV vaccines, reducing the risk of infection for many individuals.
How similar studies have gone: Other research has shown promise in understanding immune responses to vaccines, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Simpson, Rachel Marie — University of Rochester
- Study coordinator: Simpson, Rachel Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.