Understanding how molecular changes lead to early psychosis in schizophrenia
Molecular Mechanisms and Biomarkers for Disease Progression from Prodrome to Early Psychosis
['FUNDING_R01'] · MCLEAN HOSPITAL · NIH-10529311
This study is looking at how certain changes in the brain might help us understand how schizophrenia develops, so we can find ways to spot it earlier and improve treatment for people experiencing early signs of the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MCLEAN HOSPITAL (nih funded) |
| Locations | 1 site (BELMONT, UNITED STATES) |
| Trial ID | NIH-10529311 on ClinicalTrials.gov |
What this research studies
This research investigates the biological mechanisms and biomarkers that contribute to the progression of schizophrenia from its early signs to full-blown psychosis. It focuses on the role of oxidative stress and energy metabolism in the brain, examining how these factors may disrupt neuronal function and information processing. By analyzing the balance of specific molecules in the brain, the study aims to identify potential indicators of disease progression that could help in early diagnosis and treatment. Patients may be involved in assessments that measure these biological markers over time.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals showing early signs of schizophrenia or those diagnosed with schizophrenia who are willing to contribute to understanding the disease's progression.
Not a fit: Patients with established schizophrenia who are not in the prodromal phase may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective treatments for individuals at risk of developing schizophrenia.
How similar studies have performed: Previous research has indicated that examining oxidative stress and energy metabolism may provide valuable insights into schizophrenia, suggesting that this approach has potential for success.
Where this research is happening
BELMONT, UNITED STATES
- MCLEAN HOSPITAL — BELMONT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DU, FEI — MCLEAN HOSPITAL
- Study coordinator: DU, FEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Mental disorders, Mental health disorders, Psychiatric Disease, Psychiatric Disorder, psychological disorder