Understanding how mitochondrial ribosomes are assembled
Official title: Chaperoning Preassembly Modules for Mitochondrial Ribosome Assembly
Funded at Rowan University · NIH-10974362 · Data updated 2026-11-12
This study is looking at how a special protein called Mam33 helps put together the parts needed to make ribosomes in our cells' powerhouses, the mitochondria, which is important for keeping us energized, and it hopes to find out more about how problems with this process might be connected to diseases like aging and cancer.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rowan University NIH-funded |
| Lab location | 1 site (Glassboro, United States) |
| Project start | August 5, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $463,083 |
| NIH project number | 1R15GM155795-01 |
| Project ID | NIH-10974362 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with mitochondrial diseases or conditions related to energy production, such as certain degenerative disorders and cancers.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or those not experiencing energy production issues may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the assembly of ribosomes in mitochondria, which are crucial for energy production in cells. It focuses on a specific protein called Mam33 that helps guide the assembly of mitochondrial ribosomal proteins. By studying how this protein interacts with other components, the research aims to uncover the unique pathways involved in mitochondrial ribosome biogenesis. This understanding could shed light on various diseases linked to mitochondrial dysfunction, including aging and cancer.
Why it matters
Potential benefit: If successful, this research could lead to new insights into mitochondrial diseases and potential therapeutic strategies to improve energy production in affected patients.
How similar studies have gone: While the specific approach of studying the Mam33 protein is novel, there has been previous success in understanding mitochondrial ribosome assembly through other methods.
Where this research is happening
-
Rowan University
Glassboro, United States Active
Researchers
- Principal investigator: Henry, Michael — Rowan University
- Study coordinator: Henry, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.