Understanding how mitochondrial function affects brain networks involved in complex thinking.
Official title: Investigating the Role of KIBRA-Dependent Synaptic Function on Hippocampal and Cortical Network Mechanisms Underlying Complex Cognition
Funded at Duke University · NIH-10702049 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called mitochondria affect brain function, especially when we're stressed, to better understand their role in conditions like bipolar disorder and depression, and it hopes to help improve our understanding of how these issues impact thinking and behavior.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $77,826 |
| NIH project number | 8K00MH138410-03 |
| Project ID | NIH-10702049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with bipolar disorder, schizophrenia, major depressive disorder, or PTSD.
✕Less likely to help
Patients without any neuropsychiatric disorders or those not experiencing stress-related cognitive issues may not benefit from this research.
What this research studies
This research investigates the role of mitochondria in brain networks that support complex cognitive functions, particularly under stress. It aims to understand how mitochondrial dysfunction contributes to neuropsychiatric disorders like bipolar disorder and depression. By employing a combination of molecular, cellular, and circuit-level analyses, the study will explore how mitochondrial processes influence brain activity and behavior. The findings could provide insights into the mechanisms that underlie cognitive changes in both healthy and affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating stress-related neuropsychiatric disorders.
How similar studies have gone: Previous research has shown that mitochondrial dysfunction is linked to various neuropsychiatric disorders, suggesting that this approach could yield meaningful insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Quigley, Lilyana Dream — Duke University
- Study coordinator: Quigley, Lilyana Dream
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.