Understanding how mitochondrial function affects brain networks involved in complex thinking.
Investigating the Role of KIBRA-Dependent Synaptic Function on Hippocampal and Cortical Network Mechanisms Underlying Complex Cognition
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-10702049
This study is looking at how tiny parts of our cells called mitochondria affect brain function, especially when we're stressed, to better understand their role in conditions like bipolar disorder and depression, and it hopes to help improve our understanding of how these issues impact thinking and behavior.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10702049 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitochondria in brain networks that support complex cognitive functions, particularly under stress. It aims to understand how mitochondrial dysfunction contributes to neuropsychiatric disorders like bipolar disorder and depression. By employing a combination of molecular, cellular, and circuit-level analyses, the study will explore how mitochondrial processes influence brain activity and behavior. The findings could provide insights into the mechanisms that underlie cognitive changes in both healthy and affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with bipolar disorder, schizophrenia, major depressive disorder, or PTSD.
Not a fit: Patients without any neuropsychiatric disorders or those not experiencing stress-related cognitive issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating stress-related neuropsychiatric disorders.
How similar studies have performed: Previous research has shown that mitochondrial dysfunction is linked to various neuropsychiatric disorders, suggesting that this approach could yield meaningful insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QUIGLEY, LILYANA DREAM — DUKE UNIVERSITY
- Study coordinator: QUIGLEY, LILYANA DREAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bipolar Disorder