Understanding how mitochondrial dysfunction leads to heart rhythm problems
Official title: The mechanisms and roles of mitochondria dysfunction in cardiac arrhythmogenesis
Funded at Ohio State University · NIH-11099980 · Data updated 2026-11-12
This study is looking at how problems with tiny parts of your cells called mitochondria can lead to irregular heartbeats, especially when you're stressed, and it aims to find new ways to help people with heart disease feel better and have healthier hearts.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $685,631 |
| NIH project number | 5R01HL166604-03 |
| Project ID | NIH-11099980 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with heart disease, particularly those experiencing arrhythmias or related conditions.
✕Less likely to help
Patients without any heart conditions or those who do not experience arrhythmias may not benefit from this research.
What this research studies
This research investigates the role of mitochondria in causing abnormal heart rhythms, particularly during stress. It focuses on how disturbances in mitochondrial function affect calcium cycling in heart cells, which is crucial for maintaining a normal heartbeat. By exploring the mechanisms behind these disturbances, the research aims to identify new strategies to improve heart function and reduce the risk of arrhythmias in patients with heart disease. The study involves both laboratory experiments and potential applications for patient care.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the risk of life-threatening arrhythmias.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial dysfunction and its impact on heart health, suggesting that this approach could lead to significant advancements.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Terentyev, Dmitry a — Ohio State University
- Study coordinator: Terentyev, Dmitry a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.