Understanding how mitochondria transport important molecules
Official title: A systems approach to decode mitochondrial metabolite transport
Funded at Yale University · NIH-11072028 · Data updated 2026-11-12
This study is looking at how certain proteins help move important energy molecules in brain cells, which could help us understand their role in keeping our brains healthy or how they might contribute to brain diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $376,875 |
| NIH project number | 5R35GM150619-03 |
| Project ID | NIH-11072028 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions or those interested in the biological mechanisms underlying brain health.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or brain metabolism may not benefit from this research.
What this research studies
This research investigates the mechanisms by which mitochondria, the energy-producing structures in cells, transport metabolites that are crucial for cellular function. By focusing on a family of proteins known as SLC25 transporters, the study aims to identify the specific molecules these transporters carry and how their function affects neuronal metabolism. Using advanced techniques, including genetic manipulation and in vitro models of neurons derived from stem cells, the research seeks to uncover the role of these transporters in brain health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new insights into brain disorders and potential therapeutic targets for improving neuronal function.
How similar studies have gone: Previous research has shown promise in understanding mitochondrial transport mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Shen, Hongying — Yale University
- Study coordinator: Shen, Hongying
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.