Understanding how mitochondria support learning and memory
Official title: Identifying Mitochondrial Mechanisms Driving Learning and Memory
Funded at Max Planck Florida Corporation · NIH-10909599 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called mitochondria help our brains get the energy they need for learning and memory, especially in conditions like Alzheimer's disease, to find new ways to improve cognitive health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Max Planck Florida Corporation NIH-funded |
| Lab location | 1 site (Jupiter, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,737,000 |
| NIH project number | 1DP2MH140148-01 |
| Project ID | NIH-10909599 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with early-stage Alzheimer's disease or other forms of dementia who are experiencing cognitive decline.
✕Less likely to help
Patients with advanced neurodegenerative diseases or those without cognitive impairment may not benefit from this research.
What this research studies
This research investigates the role of mitochondria in providing energy necessary for learning and memory processes in the brain. It focuses on how these organelles supply ATP, the energy currency, at neuronal synapses, which are critical for cognitive functions. The study employs advanced techniques, including CRISPR-based screens, to explore the mechanisms by which mitochondria are stabilized and how they contribute to synaptic plasticity. By understanding these processes, the research aims to uncover new insights into cognitive impairment associated with conditions like Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing cognitive function and treating memory-related disorders.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial functions in neuronal health, indicating potential for success in this novel approach.
Where this research is happening
-
Max Planck Florida Corporation
Jupiter, United States Active
Researchers
- Principal investigator: Rangaraju, Vidhya — Max Planck Florida Corporation
- Study coordinator: Rangaraju, Vidhya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.