Understanding how brain signaling affects learning and memory.
Official title: Neuronal Intracellular Signaling Underlying Synaptic, Circuit and Behavioral Plasticity
Funded at Max Planck Florida Corporation · NIH-11091597 · Data updated 2026-11-12
This study is looking at how tiny parts of brain cells help us learn and remember, using special tools to see and change their activity in both brain samples and living animals, so we can better understand how our brains work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Max Planck Florida Corporation NIH-funded |
| Lab location | 1 site (Jupiter, UNITED STATES) |
| Project start | May 1, 2020 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,158,000 |
| NIH project number | 5R35NS116804-06 |
| Project ID | NIH-11091597 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with non-neurological conditions or those without cognitive impairments may not benefit from this research.
What this research studies
This research investigates the intricate signaling processes within dendritic spines of neurons, which are crucial for learning and memory. By utilizing advanced imaging techniques and optogenetic tools, the study aims to measure and manipulate these signaling activities in both brain slices and live animals. The goal is to uncover how these signaling pathways contribute to synaptic and behavioral plasticity, ultimately enhancing our understanding of brain function.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving cognitive function in patients with Alzheimer's disease and other forms of dementia.
How similar studies have gone: Previous research has shown promising results in understanding neuronal signaling and its implications for cognitive function, suggesting that this approach could yield significant insights.
Where this research is happening
-
Max Planck Florida Corporation
Jupiter, United States Active
Researchers
- Principal investigator: Yasuda, Ryohei — Max Planck Florida Corporation
- Study coordinator: Yasuda, Ryohei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.