Understanding how microRNAs affect the behavior of a common virus linked to cancer
microRNA Regulation of Gamma-herpesvirus Latency and Reactivation
This study is looking at how tiny molecules called microRNAs affect the Epstein-Barr virus in people with weakened immune systems, like those with HIV/AIDS or who have had organ transplants, to better understand why some patients have a hard time getting rid of the virus and to help find new ways to treat related illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10532215 on NIH RePORTER |
What this research studies
This research investigates the role of microRNAs in the Epstein-Barr virus (EBV), which can lead to various cancers in individuals with weakened immune systems, such as those with HIV/AIDS or organ transplant recipients. The study aims to uncover how these small RNA molecules influence the virus's ability to remain dormant and reactivate, potentially leading to persistent infections. By examining the molecular mechanisms involved, the research seeks to provide insights into why some patients struggle to clear the virus from their systems. This could ultimately help in developing new therapeutic strategies for managing EBV-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with weakened immune systems, particularly those living with HIV/AIDS or who have undergone organ transplants.
Not a fit: Patients without immune deficiencies or those not infected with Epstein-Barr virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with EBV-related cancers and better management of persistent infections.
How similar studies have performed: Previous research has shown promising results in understanding the role of microRNAs in viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Skalsky, Rebecca L — Oregon Health & Science University
- Study coordinator: Skalsky, Rebecca L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.