Understanding how microRNAs affect lupus nephritis in patients with lupus
Characterization of the lupus nephritis microRNAome
This study is looking at tiny molecules in your blood that might help doctors understand how lupus can affect your kidneys, with the hope of finding new ways to predict and manage kidney problems for people with lupus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10480034 on NIH RePORTER |
What this research studies
This research investigates the role of microRNAs found in serum exosomes in relation to Systemic Lupus Erythematosus (SLE) and its progression to lupus nephritis (LN). By analyzing these microRNAs, the study aims to identify potential biomarkers that could help in predicting the risk and severity of LN in SLE patients. The approach involves advanced transcriptome sequencing techniques to characterize these microRNAs and their influence on gene expression related to kidney health. This could lead to improved monitoring and treatment strategies for individuals affected by these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Systemic Lupus Erythematosus, particularly those at risk for developing lupus nephritis.
Not a fit: Patients without a diagnosis of Systemic Lupus Erythematosus or those who do not have any risk factors for lupus nephritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new biomarkers for early detection and monitoring of lupus nephritis in patients with lupus, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using microRNAs as biomarkers in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Brown, Elizabeth E — University of Alabama at Birmingham
- Study coordinator: Brown, Elizabeth E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.