Understanding how metals are transported in cells
Principles of selectivity and translocation in transition metal transporters, metallochaperones, and associated metalloproteins
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS DALLAS · NIH-11009007
This study is looking at how our cells take in important metals and get rid of harmful ones, which could help us understand better how metal imbalances affect our health and diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS DALLAS (nih funded) |
| Locations | 1 site (RICHARDSON, UNITED STATES) |
| Trial ID | NIH-11009007 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which essential metals are transported across cell membranes and how cells manage both the uptake of necessary metals and the removal of toxic ones. By using a combination of chemical, biophysical, and structural techniques, the research aims to uncover the principles that govern metal selectivity and transport in various protein families. This could lead to a better understanding of how these processes affect cellular function and health, particularly in the context of diseases related to metal imbalances.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to metal transport disorders or those affected by bacterial infections.
Not a fit: Patients with conditions unrelated to metal transport or those not affected by bacterial diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases caused by metal imbalances, including certain cancers and bacterial infections.
How similar studies have performed: Other research has shown promise in understanding metal transport mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
RICHARDSON, UNITED STATES
- UNIVERSITY OF TEXAS DALLAS — RICHARDSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MELONI, GABRIELE — UNIVERSITY OF TEXAS DALLAS
- Study coordinator: MELONI, GABRIELE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer, bacteria infection, bacterial disease, Bacterial Infections