Understanding how metabolism affects glioma growth
Official title: Metabolic mechanisms of glioma progression
Funded at Ut Southwestern Medical Center · NIH-11048910 · Data updated 2026-11-12
This study is looking at how changes in metabolism might help aggressive brain tumors called gliomas grow and resist treatment, using samples from patients to find new ways to help those affected by these tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $682,596 |
| NIH project number | 1R01CA289260-01A1 |
| Project ID | NIH-11048910 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with gliomas, particularly those with high-grade tumors.
✕Less likely to help
Patients with non-cancerous brain conditions or those with low-grade gliomas may not benefit directly from this research.
What this research studies
This research investigates the metabolic mechanisms that contribute to the progression of gliomas, which are aggressive brain tumors. By analyzing surgical brain tissue samples from patients, the study aims to identify specific metabolic changes associated with high-grade gliomas compared to lower-grade tumors and non-malignant tissues. The approach involves advanced mass spectrometry to quantify various metabolites, providing insights into how these metabolic alterations may drive tumor growth and resistance to treatment. The ultimate goal is to translate these findings into new therapeutic strategies for patients suffering from gliomas.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatment options that specifically target the metabolic pathways involved in glioma progression.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could yield significant advancements in glioma treatment.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Mcbrayer, Samuel Kent — Ut Southwestern Medical Center
- Study coordinator: Mcbrayer, Samuel Kent
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.