Understanding how metabolism affects glioma growth
Metabolic mechanisms of glioma progression
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11048910
This study is looking at how changes in metabolism might help aggressive brain tumors called gliomas grow and resist treatment, using samples from patients to find new ways to help those affected by these tumors.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11048910 on ClinicalTrials.gov |
What this research studies
This research investigates the metabolic mechanisms that contribute to the progression of gliomas, which are aggressive brain tumors. By analyzing surgical brain tissue samples from patients, the study aims to identify specific metabolic changes associated with high-grade gliomas compared to lower-grade tumors and non-malignant tissues. The approach involves advanced mass spectrometry to quantify various metabolites, providing insights into how these metabolic alterations may drive tumor growth and resistance to treatment. The ultimate goal is to translate these findings into new therapeutic strategies for patients suffering from gliomas.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with gliomas, particularly those with high-grade tumors.
Not a fit: Patients with non-cancerous brain conditions or those with low-grade gliomas may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatment options that specifically target the metabolic pathways involved in glioma progression.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could yield significant advancements in glioma treatment.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCBRAYER, SAMUEL KENT — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: MCBRAYER, SAMUEL KENT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Cancer