Understanding how metabolic signals influence T cell development
Bidirectional metabolic signaling in follicular helper T cell differentiation
This study is looking at how the way our bodies use nutrients affects certain immune cells that help produce strong antibodies, which could lead to better treatments for autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10687027 on NIH RePORTER |
What this research studies
This research investigates the role of metabolic signaling in the differentiation of follicular helper T cells, which are crucial for the production of high-affinity antibodies. By examining how nutrient inputs and metabolic pathways affect T cell responses, the study aims to uncover the mechanisms that drive immune cell function. The research employs various methodologies, including genetic models and systems biology approaches, to explore the interactions between immune signals and metabolism. Patients may benefit from insights gained into how to enhance immune responses, particularly in the context of autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with autoimmune diseases or conditions affecting antibody production.
Not a fit: Patients with non-autoimmune conditions or those not affected by antibody production issues may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses in patients with autoimmune diseases.
How similar studies have performed: Other research has shown promising results in understanding metabolic pathways in immune responses, indicating that this approach has potential for significant findings.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Chi, Hongbo — St. Jude Children's Research Hospital
- Study coordinator: Chi, Hongbo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.