Understanding how metabolic changes affect the stability of atherosclerotic plaques
Role of Metabolic Reprogramming in Formation and Maintenance of the Acta2+ Atherosclerotic Lesion Protective Fibrous Cap
This study is looking at how certain cells in the body help keep heart plaque stable, which is important for preventing heart attacks and strokes, and it uses mice to learn more about how these cells work, especially when eating a high-fat diet.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10860930 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that influence the stability of atherosclerotic plaques, which can lead to serious cardiovascular events. By studying specific genetic modifications in mice, the researchers aim to uncover how different cell types contribute to the formation of a protective fibrous cap around these plaques. The approach involves analyzing the roles of smooth muscle cells, endothelial cells, and macrophages in plaque stability, particularly under conditions that mimic a high-fat diet. Patients may benefit from insights gained that could lead to new therapeutic strategies for preventing heart attacks and strokes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals at high risk for atherosclerosis or those with existing cardiovascular disease.
Not a fit: Patients with conditions unrelated to atherosclerosis or those who do not have cardiovascular risk factors may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance plaque stability and reduce the risk of heart attacks and strokes.
How similar studies have performed: Previous research has shown promising results in understanding the cellular mechanisms of atherosclerosis, suggesting that this approach could yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Owens, Gary K — University of Virginia
- Study coordinator: Owens, Gary K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.