Understanding How Memories Are Stored in the Brain
Epigenetic Mechanisms of Memory Storage
This project explores how brain cells store long-term memories, especially in conditions like autism and bipolar disorder.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11082329 on NIH RePORTER |
What this research studies
Our brains create lasting memories through specific changes in how genes are turned on and off within cells. These changes, known as epigenetic events, involve modifications to DNA and the proteins that organize it, as well as how RNA helps regulate gene activity. When these processes don't work correctly, it can lead to memory problems often seen in certain brain disorders. We aim to uncover new epigenetic mechanisms that are crucial for memory storage and brain cell communication. We are also developing advanced tools to analyze these changes at the level of individual brain cells.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patient participation at this stage, but its findings could eventually benefit individuals experiencing memory impairments related to autism or bipolar disorder.
Not a fit: Patients seeking immediate clinical treatment or direct intervention for their conditions would not receive direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of memory difficulties in psychiatric conditions like autism and bipolar disorder, potentially paving the way for new treatment approaches.
How similar studies have performed: While the broad field of epigenetics and memory is well-established, this project is exploring novel metabolic sources and regulatory mechanisms, building on the team's prior successes in defining new epigenetic factors.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Abel, Edwin Ted G. — University of Iowa
- Study coordinator: Abel, Edwin Ted G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.