Understanding how MEIS1 affects blood vessel health
Official title: Function and Regulation of MEIS1 in Vascular Disease
Funded at Augusta University · NIH-10894107 · Data updated 2026-11-12
This study is looking at a protein called MEIS1 to see how it affects the cells in your blood vessels, which is important for keeping your arteries healthy, especially if you have conditions like atherosclerosis or have had a procedure to open blocked arteries; the goal is to find new ways to help treat these issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $113,520 |
| NIH project number | 5K99HL169827-02 |
| Project ID | NIH-10894107 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with atherosclerosis or those who have undergone angioplasty and are experiencing related vascular issues.
✕Less likely to help
Patients with vascular diseases unrelated to smooth muscle cell function or those without atherosclerosis may not benefit from this research.
What this research studies
This research investigates the role of a protein called MEIS1 in the behavior of vascular smooth muscle cells (VSMCs), which are crucial for the health of medium- and large-sized arteries. By examining how MEIS1 influences the changes in these cells during vascular diseases like atherosclerosis and post-angioplasty restenosis, the research aims to identify new strategies for treating these conditions. The approach includes studying the binding of MEIS1 to specific genes that regulate VSMC function and assessing its expression in human arteries affected by disease. This could lead to better understanding and potential therapies for patients with vascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve vascular health and reduce complications from diseases like atherosclerosis.
How similar studies have gone: While there has been limited research on MEIS1 in vascular smooth muscle cells, the exploration of its role in this context is relatively novel and untested.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Salem, Amr — Augusta University
- Study coordinator: Salem, Amr
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.