Understanding how MBNL proteins help localize RNA in neurons for brain health.
Mechanism and Function Of MBNL Mediated mRNA Localization in Neuronal Development and Neurologic Disease
This study is looking at how certain proteins help move RNA around in brain cells, which is important for keeping our brain connections healthy, and it hopes to find out how problems in this process might be linked to neurological disorders, ultimately helping patients understand their conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10827369 on NIH RePORTER |
What this research studies
This research investigates the role of MBNL proteins in the localization of RNA within neurons, which is crucial for the development and maintenance of synaptic connections. By exploring the mechanisms that govern RNA transport and local translation, the study aims to uncover how disruptions in these processes may contribute to various neurological disorders. The research employs advanced molecular biology techniques to identify RNA elements and proteins involved in this localization process, potentially leading to new insights into brain function and disease. Patients may benefit from a better understanding of the underlying causes of their neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with neurological disorders, particularly those related to RNA localization such as Charcot-Marie-Tooth disease.
Not a fit: Patients with neurological conditions unrelated to RNA localization or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurological disorders linked to RNA localization issues.
How similar studies have performed: Previous research has shown promising results in understanding RNA localization mechanisms, suggesting that this approach may yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Bassell, Gary J — Emory University
- Study coordinator: Bassell, Gary J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.