Understanding how maternal depression affects children's emotional development

Charting Positive Valence Systems Trajectories in Offspring of Depressed Mothers to Predict Internalizing Symptoms in Early Childhood

NIH-funded research Pennsylvania State University, the · NIH-10979020

This study looks at how a mother's depression can affect her young child's feelings and behavior, especially for kids who might be more likely to develop anxiety or depression themselves, so we can find ways to help them early on.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionPennsylvania State University, the NIH-funded
Lab location1 site (University Park, United States)
Project IDNIH-10979020 on NIH RePORTER

What this research studies

This research investigates the impact of maternal depression on the emotional and behavioral development of children, particularly focusing on those at high risk for developing anxiety and depressive disorders. By studying the trajectories of Positive Valence Systems in young children, the research aims to identify key markers of vulnerability that can be targeted for early prevention efforts. The approach involves a multimodal, accelerated longitudinal design, which will track changes in emotional responsiveness over time in children of depressed mothers. This study seeks to fill gaps in existing knowledge by examining these effects in preschool-aged children, rather than just adolescents.

Who could benefit from this research

Good fit: Ideal candidates for this research are children aged 0-11 years who have mothers with a history of depression.

Not a fit: Children whose mothers do not have a history of depression may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to early interventions that significantly reduce the risk of anxiety and depression in children of depressed mothers.

How similar studies have performed: Previous research has shown that understanding emotional development in high-risk youth can lead to effective prevention strategies, indicating that this approach has potential for success.

Where this research is happening

University Park, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Anxiety Disorders
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.