Understanding how manganese affects Salmonella's response to nitric oxide stress
The role of manganese homeostasis in the nitric oxide stress response of Salmonella enterica serovar Typhimurium
This study is looking at how manganese helps the bacteria Salmonella survive stress from our immune system, which could lead to new ways to treat infections.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhodes College NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10514182 on NIH RePORTER |
What this research studies
This research investigates how the metal manganese helps the bacteria Salmonella survive and recover from stress caused by nitric oxide, a molecule produced by our immune system to fight infections. The study will explore the mechanisms by which manganese influences the bacteria's ability to resist damage and continue growing under stress. Researchers will use various assays and probes to measure the bacteria's activity and health, focusing on how manganese impacts their cellular functions and DNA integrity. By understanding these processes, the research aims to uncover new insights into bacterial infections and potential treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are affected by bacterial infections, particularly those caused by Salmonella.
Not a fit: Patients with infections caused by bacteria other than Salmonella may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bacterial infections by targeting manganese-related pathways.
How similar studies have performed: While the specific focus on manganese in this context is novel, previous research has shown that understanding bacterial stress responses can lead to significant advancements in treating infections.
Where this research is happening
Memphis, United States
- Rhodes College — Memphis, United States (Active)
Researchers
- Principal investigator: Frawley, Elaine R. — Rhodes College
- Study coordinator: Frawley, Elaine R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.