Understanding how macrophages contribute to lung inflammation in ARDS
REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN ARDS
This study is looking at how a protein called NFATc3 in immune cells affects lung inflammation in people with Acute Respiratory Distress Syndrome (ARDS), and it aims to find new ways to help improve lung function and reduce inflammation for those who are struggling with this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10866487 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, NFATc3, in macrophages and how it affects lung inflammation in patients with Acute Respiratory Distress Syndrome (ARDS). The team is using advanced techniques, including a novel peptide that inhibits NFATc3, to explore its effects on lung function and inflammation. By studying human lung macrophages and animal models, they aim to identify the molecular pathways involved in ARDS and how to mitigate its severity. This could lead to new therapeutic strategies for patients suffering from this serious condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with Acute Respiratory Distress Syndrome (ARDS).
Not a fit: Patients with chronic respiratory conditions or those not meeting the criteria for ARDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung function and survival rates for patients with ARDS.
How similar studies have performed: Previous studies have shown promising results in targeting NFATc3 in animal models, suggesting potential for success in human applications.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Christman, John W — Ohio State University
- Study coordinator: Christman, John W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.