Understanding how lymph node cells can help manage autoimmune diabetes
Official title: Unraveling the tolerogenic potential of lymph node fibroblastic reticular networks in autoimmune diabetes
Funded at Columbia University Health Sciences · NIH-10998368 · Data updated 2026-11-12
This study is looking at special cells in the lymph nodes that might help control the immune system's response in people with type 1 diabetes, with the hope of finding new ways to protect insulin-producing cells in the pancreas and improve treatment options for those living with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $602,531 |
| NIH project number | 1R01DK141150-01 |
| Project ID | NIH-10998368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 diabetes who may benefit from new therapeutic approaches targeting immune tolerance.
✕Less likely to help
Patients with type 2 diabetes or other forms of diabetes unrelated to autoimmune mechanisms may not benefit from this research.
What this research studies
This research investigates the role of specific cells in the lymph nodes, known as fibroblastic reticular cells (FRCs), in controlling immune responses related to type 1 diabetes. By studying how these cells present antigens to T cells, the research aims to uncover mechanisms that could restore tolerance to insulin-producing cells in the pancreas. The approach involves examining both animal models and human tissue samples to understand the changes in FRCs during autoimmune diabetes. The ultimate goal is to identify new therapeutic strategies that could prevent or treat this condition.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that help maintain immune tolerance in patients with type 1 diabetes.
How similar studies have gone: Previous studies have shown promise in using similar approaches to manipulate immune responses, suggesting potential for success in this area as well.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Creusot, Remi J — Columbia University Health Sciences
- Study coordinator: Creusot, Remi J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.