Understanding how lung signals affect immune cells in the lungs during health and infection
Linking steady-state cytokine signaling to alveolar macrophage function in homeostasis and lung infection
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10885051
This study is looking at how certain signals in the lungs affect immune cells that help keep your lungs healthy, focusing on a protein called CISH and how it changes the way these cells respond to infections, with the hope of finding better treatments for lung infections like pneumonia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10885051 on ClinicalTrials.gov |
What this research studies
This research investigates how specific signals in the lungs influence the function of alveolar macrophages, which are immune cells that help maintain lung health and respond to infections. The study focuses on understanding the role of a protein called CISH and its impact on macrophage behavior, particularly how it affects their ability to switch between anti-inflammatory and pro-inflammatory responses. By exploring these mechanisms, the research aims to uncover new therapeutic targets that could improve treatment for lung infections like bacterial pneumonia.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic lung diseases or those who are at risk for bacterial infections.
Not a fit: Patients with non-respiratory conditions or those without any history of lung disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses in the lungs, potentially reducing mortality from bacterial pneumonia.
How similar studies have performed: Previous research has shown promising results in understanding immune cell functions in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOTTSCHALK, RACHEL A — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: GOTTSCHALK, RACHEL A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections