Understanding how lung inflammation worsens during acute lung injury
Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung Injury
['FUNDING_R01'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10756078
This study is looking at how lung injuries from infections or sepsis can cause more inflammation, and it aims to find out which proteins and channels in our cells make this worse, so we can discover better ways to help patients heal.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10756078 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that lead to increased inflammation in the lungs during acute lung injury, particularly focusing on how certain signals from damaged cells can amplify this response. The study aims to identify specific proteins and ion channels that contribute to the severity of lung injury caused by infections or sepsis. By understanding these processes, researchers hope to find new ways to mitigate lung damage and improve recovery for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients experiencing acute lung injury due to infections or sepsis.
Not a fit: Patients with chronic lung conditions unrelated to acute injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce lung inflammation and improve outcomes for patients with acute lung injury.
How similar studies have performed: Previous research has shown success in understanding inflammatory responses in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REHMAN, JALEES — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: REHMAN, JALEES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections