Understanding how lung cells respond to injury
Official title: Functional diversity of lung pericytes in lung injury
Funded at University of Washington · NIH-10988231 · Data updated 2026-11-12
This study is looking at special lung cells called pericytes to see how they help the lungs heal and manage inflammation after injuries like those caused by the flu, which could be helpful for people dealing with serious lung issues like Acute Respiratory Distress Syndrome (ARDS).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $575,049 |
| NIH project number | 5R01HL166273-03 |
| Project ID | NIH-10988231 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing acute lung injuries, particularly those related to influenza or similar respiratory conditions.
✕Less likely to help
Patients with chronic lung diseases or those not experiencing acute lung injury may not benefit from this research.
What this research studies
This research investigates the role of specific lung cells called pericytes in the context of lung injuries, particularly those caused by influenza infection. The study aims to understand how these cells interact with other cells in the lung to regulate inflammation and repair processes. By analyzing gene activity in these cells, researchers hope to uncover their diverse functions during lung injury and how they contribute to conditions like Acute Respiratory Distress Syndrome (ARDS). The research employs advanced techniques to explore the mechanisms of cell communication and immune response in the lungs.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery from lung injuries and reduce complications in patients with ARDS.
How similar studies have gone: Previous research has shown promising results in understanding the role of pericytes in other organs, suggesting potential for success in this novel approach to lung injury.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Hung, Chi F — University of Washington
- Study coordinator: Hung, Chi F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.