Understanding how lung cells maintain health and respond to injury
Mechanisms of Alveolar Homeostasis, Injury, Regeneration, and Fibrosis
This study is looking at how tiny air sacs in the lungs stay healthy and how they react when they get hurt, especially in conditions like ARDS and IPF, to help find better treatments for people with these serious lung issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11044102 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that keep the alveoli, the tiny air sacs in the lungs, healthy and how they respond to injury. It focuses on conditions like acute respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis (IPF), which can severely affect lung function. By studying the interactions between different lung cells, the research aims to uncover why these cells fail to regenerate properly after injury, leading to chronic lung diseases. Patients may benefit from insights that could lead to new treatments for these serious conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from acute respiratory distress syndrome or idiopathic pulmonary fibrosis.
Not a fit: Patients with stable chronic lung diseases that do not involve acute injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve lung recovery and function for patients with severe lung diseases.
How similar studies have performed: Previous research has shown promise in understanding lung cell behavior, but this study aims to explore novel mechanisms that have not been fully tested.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Zemans, Rachel Lynne — University of Michigan at Ann Arbor
- Study coordinator: Zemans, Rachel Lynne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.