Understanding how lung cells communicate to improve treatment for acute lung injury
Decoding temporal epithelial signaling programs to restore homeostasis in acute lung injury
This study is looking at how lung cells behave during serious breathing problems like acute lung injury and ARDS, to find better ways to treat these conditions and help patients breathe easier, especially those affected by infections like COVID-19.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10868723 on NIH RePORTER |
What this research studies
This research investigates the complex signaling pathways that govern the behavior of lung epithelial cells, particularly in the context of acute lung injury and acute respiratory distress syndrome (ALI/ARDS). By utilizing advanced live-cell technology, the researchers aim to decode the timing and coordination of these signaling events, which are crucial for regulating inflammation and cell function. The study focuses on how these pathways can be targeted with existing treatments to restore normal lung function and improve patient outcomes. Patients may benefit from insights gained into more effective therapies for severe respiratory conditions, including those exacerbated by infections like COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing acute lung injury or acute respiratory distress syndrome, particularly those with severe respiratory infections.
Not a fit: Patients with chronic lung conditions that do not involve acute injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from acute lung injury and related respiratory conditions.
How similar studies have performed: Previous research has shown promise in targeting similar signaling pathways for improving outcomes in lung diseases, indicating that this approach could be effective.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Albeck, John G. — University of California at Davis
- Study coordinator: Albeck, John G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.