Understanding how Lp(a) genetics raise heart disease risk
Unraveling the Complexities of Lp(a): From Genes to Function
Researchers will analyze genetic differences and the makeup of Lp(a) particles in people from diverse ethnic groups to learn why some have higher heart disease risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11173580 on NIH RePORTER |
What this research studies
This project uses blood samples from a multi-ethnic group at Columbia University to study Lp(a), a particle that can raise heart disease risk. Scientists will map genetic differences in the LPA gene—including variants in the KIV-2 region—and measure the particle's proteins and fats using advanced lab techniques. They will compare results across Black, Hispanic, and White participants to see which genetic changes link to higher Lp(a) levels and altered particle function. The team aims to connect specific variants to how the Lp(a) particle behaves and to explain ethnic differences in Lp(a) levels.
Who could benefit from this research
Good fit: Ideal participants are adults with elevated Lp(a) or people from Black, Hispanic, or other diverse backgrounds who can provide blood samples and medical history.
Not a fit: People without elevated Lp(a) or those unable to attend the study site are unlikely to receive direct benefits from this research in the short term.
Why it matters
Potential benefit: If successful, this work could improve how we identify people at high risk from Lp(a) and guide development of targeted tests or therapies.
How similar studies have performed: Prior genetic and epidemiologic studies have linked Lp(a) to cardiovascular risk and mapped KIV-2 variants, but combining multi-omic profiling with diverse human cohorts is a relatively new approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Reyes-Soffer, Gissette — Columbia University Health Sciences
- Study coordinator: Reyes-Soffer, Gissette
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.