Understanding how lower chlorinated PCBs affect brain development
Official title: Investigating the cellular and molecular mechanisms of lower-chlorinated polychlorinated biphenyl developmental neurotoxicity
Funded at University of California at Davis · NIH-10918061 · Data updated 2026-11-12
This study is looking at how certain chemicals called PCBs, which can be found in the environment, might affect brain development in children, especially when pregnant women are exposed to them.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | September 30, 2023 |
| Project end | September 29, 2025 |
| Funding year | 2024 |
| Award (this year) | $41,568 |
| NIH project number | 5F31ES035282-02 |
| Project ID | NIH-10918061 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women and their children, particularly those exposed to lower chlorinated PCBs.
✕Less likely to help
Patients who are not pregnant or do not have children at risk for neurodevelopmental disorders may not benefit from this research.
What this research studies
This research investigates the impact of lower chlorinated polychlorinated biphenyls (PCBs) on brain development, particularly focusing on how these chemicals may contribute to neurodevelopmental disorders in children. The study aims to identify the cellular and molecular mechanisms through which these compounds affect neural growth and signaling pathways. By examining the effects of specific PCB congeners found in pregnant women, the research seeks to fill a critical gap in understanding the risks associated with environmental exposure to these substances during gestation.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of neurodevelopmental disorders linked to environmental exposures in children.
How similar studies have gone: While there has been extensive research on higher chlorinated PCBs, this investigation into lower chlorinated variants is relatively novel and has not been extensively studied.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Badley, Jessie Renee — University of California at Davis
- Study coordinator: Badley, Jessie Renee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.