Understanding how long-lived plasma cells are generated in the bone marrow and spleen.
Molecular Mechanisms of Human Long-lived Plasma Cell Generation in the Bone Marrow and Spleen
This study is looking at how certain immune cells, which help keep us protected from diseases after vaccination, develop and stay alive in our bodies, focusing on the roles of different tissues like bone marrow and spleen.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11004332 on NIH RePORTER |
What this research studies
This research investigates the processes that lead to the development and survival of long-lived plasma cells (LLPCs), which are crucial for maintaining long-term immunity from vaccines. The study will explore the roles of different tissue environments, particularly the bone marrow and spleen, in supporting these cells. By examining the molecular mechanisms involved in the signaling pathways that promote the generation of antibody-secreting cells, the research aims to uncover how these cells mature and persist in the body over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who may have autoimmune conditions or are interested in vaccine response.
Not a fit: Patients with acute infections or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune memory, potentially leading to improved vaccine strategies and treatments for autoimmune diseases.
How similar studies have performed: Other research has shown promising results in understanding immune cell longevity and function, suggesting that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Lee, Frances Eun-Hyung — Emory University
- Study coordinator: Lee, Frances Eun-Hyung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.