Understanding how LMO7 affects atherosclerosis
Role of LMO7 in atherosclerosis
This study is looking at a protein called LMO7 to see how it affects the stability of plaque in blood vessels, which can lead to heart attacks and strokes, with the hope of finding new ways to treat atherosclerosis that could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10670757 on NIH RePORTER |
What this research studies
This research investigates the role of the LMO7 protein in the development and stability of atherosclerotic plaques, which are a major cause of cardiovascular diseases like heart attacks and strokes. By studying how LMO7 influences vascular smooth muscle cells and their ability to stabilize plaques, the research aims to uncover new molecular mechanisms that could lead to better treatments. The approach includes using animal models to observe the effects of manipulating LMO7 levels on plaque formation and stability. Patients may benefit from insights gained that could lead to novel therapies for atherosclerosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for atherosclerosis or those with existing cardiovascular conditions.
Not a fit: Patients who do not have cardiovascular disease or significant risk factors for atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating atherosclerosis and its associated cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of molecular mechanisms in atherosclerosis, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Martin, Kathleen Ann — Yale University
- Study coordinator: Martin, Kathleen Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.