Understanding how liver fat affects heart health and blood pressure
Official title: Novel liver-mediated mechanisms in hypertension and cardiac dysfunction
Funded at University of Mississippi Med Ctr · NIH-11129414 · Data updated 2026-11-12
This study is looking at how extra fat in the liver might affect heart health, especially for people with nonalcoholic fatty liver disease, even if they aren't overweight, to find new ways to help improve their heart function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | May 15, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $604,818 |
| NIH project number | 1R01HL174521-01A1 |
| Project ID | NIH-11129414 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with nonalcoholic fatty liver disease, particularly those who may not be overweight but are at risk for cardiovascular disease.
✕Less likely to help
Patients with cardiovascular disease unrelated to liver conditions or those without any liver fat accumulation may not benefit from this research.
What this research studies
This research investigates the relationship between liver fat accumulation and cardiovascular disease, particularly in patients with nonalcoholic fatty liver disease (NAFLD). It aims to explore how liver-mediated mechanisms contribute to hypertension and heart dysfunction, especially in individuals who may not be overweight. The study utilizes a unique animal model to examine the effects of specific genetic modifications on liver function and cardiovascular health. By understanding these mechanisms, the research seeks to identify potential therapeutic targets for improving heart health in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart health and reduce cardiovascular risks for patients with liver fat accumulation.
How similar studies have gone: Previous research has shown promising results in understanding liver-related cardiovascular risks, but this specific approach is relatively novel.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Stec, David E — University of Mississippi Med Ctr
- Study coordinator: Stec, David E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.