Understanding how liver cancer interacts with the immune system
Investigating the molecular and cellular mechanisms of virus-associated hepatocellular carcinoma
This study is looking at how liver cancer hides from the immune system and how we can help the body fight it better, especially by understanding a protein called p53, which could lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11056140 on NIH RePORTER |
What this research studies
This research investigates the complex relationship between liver cancer and the immune system, focusing on how cancer cells evade immune detection. It aims to uncover the mechanisms behind immune responses during the development and progression of liver cancer, particularly through the lens of cellular senescence, which is a process that can trigger anti-tumor immunity. By studying the role of the p53 protein in this context, the research seeks to identify potential targets for enhancing immune responses against liver cancer. Patients may benefit from insights that could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with liver cancer or those at high risk for developing it.
Not a fit: Patients with non-cancerous liver conditions or those who do not have liver cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the body's immune response against liver cancer.
How similar studies have performed: Other research has shown promising results in understanding immune interactions in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Chen, Hsuan-an — Rockefeller University
- Study coordinator: Chen, Hsuan-an
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.