Understanding how lipids change during the development of Type 1 Diabetes
Official title: Lipidome Remodeling During Development of T1D
Funded at University of North Carolina Greensboro · NIH-10816971 · Data updated 2026-11-12
This study is looking at how fats in the body might affect the development of Type 1 Diabetes, using mice to see how these fats change in different tissues as the disease progresses, which could help us find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Carolina Greensboro NIH-funded |
| Lab location | 1 site (Greensboro, United States) |
| Project start | February 1, 2020 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $340,333 |
| NIH project number | 5R01DK123499-04 |
| Project ID | NIH-10816971 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Type 1 Diabetes, particularly those with a family history of the condition.
✕Less likely to help
Patients with Type 2 Diabetes or other non-autoimmune forms of diabetes may not benefit from this research.
What this research studies
This research investigates the role of lipids, which are crucial for cell function and signaling, in the development of Type 1 Diabetes (T1D). By using advanced lipidomic technologies, the study aims to measure and analyze the changes in lipid levels in a mouse model that mimics human T1D. The researchers will profile the lipid composition in various tissues at different stages of T1D development, providing insights into how lipid metabolism may contribute to this autoimmune condition. This work could lead to a better understanding of T1D and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of Type 1 Diabetes and potentially identify new treatment strategies.
How similar studies have gone: Previous research has shown that lipid metabolism plays a significant role in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of North Carolina Greensboro
Greensboro, United States Active
Researchers
- Principal investigator: Zhang, Qibin — University of North Carolina Greensboro
- Study coordinator: Zhang, Qibin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.