Understanding how lipid droplets are regulated in the body
Lipid droplet regulation and proteome dynamics
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-10889133
This study is looking at how tiny fat storage bubbles in our cells work and change when our bodies are in different states, which could help us understand and tackle health issues like obesity, diabetes, and cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-10889133 on ClinicalTrials.gov |
What this research studies
This research investigates the role of lipid droplets, which are essential for storing fats and maintaining lipid balance in cells. It aims to uncover how these droplets function under various metabolic conditions and how their protein composition changes, which is crucial for understanding diseases like obesity, diabetes, and cancer. The researchers utilize advanced techniques such as CRISPR-Cas9 screens to manipulate genes in human cells and observe the effects on lipid droplet behavior. By identifying the mechanisms that regulate lipid storage, this research could lead to new insights into metabolic health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with metabolic disorders such as obesity, diabetes, or non-alcoholic fatty liver disease, as well as cancer patients.
Not a fit: Patients with conditions unrelated to lipid metabolism or those who do not have metabolic diseases or cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic diseases and cancers by targeting lipid droplet regulation.
How similar studies have performed: Previous research has shown promising results in understanding lipid droplet dynamics, indicating that this approach could yield valuable insights.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OLZMANN, JAMES A — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: OLZMANN, JAMES A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections