Understanding how lipid control affects eye pressure and glaucoma
Official title: Transcriptional control of lipid biogenesis in trabecular meshwork and intraocular pressure regulation
Funded at Indiana University Indianapolis · NIH-11077364 · Data updated 2026-11-12
This study is looking at how fats in the eye's drainage system affect eye pressure, which is important for people with glaucoma, and it hopes to find new ways to lower that pressure and improve treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $534,176 |
| NIH project number | 5R01EY035412-02 |
| Project ID | NIH-11077364 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with primary open-angle glaucoma or those at risk of developing elevated intraocular pressure.
✕Less likely to help
Patients with other forms of glaucoma or those without elevated intraocular pressure may not benefit from this research.
What this research studies
This research investigates the role of lipid biogenesis in the trabecular meshwork of the eye and its impact on intraocular pressure (IOP), which is crucial for managing glaucoma. The study focuses on how changes in lipid composition can influence the stiffness of eye drainage tissues, potentially leading to elevated IOP. By examining the activation of a transcription factor called SREBP under mechanical stress, the research aims to uncover new mechanisms that could help lower IOP and improve patient outcomes. Patients may benefit from insights that could lead to innovative treatments for glaucoma.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for lowering intraocular pressure in glaucoma patients, potentially preserving vision.
How similar studies have gone: While the specific approach of targeting lipid biogenesis in the trabecular meshwork is novel, similar research has shown promise in understanding IOP regulation and glaucoma treatment.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Pattabiraman, Padmanabhan Paranji — Indiana University Indianapolis
- Study coordinator: Pattabiraman, Padmanabhan Paranji
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.