Understanding how kindlin-3 helps blood cells stick to blood vessels
Mechanism of kindlin-3-dependent integrin activation
This study is looking at how a protein called kindlin-3 helps blood cells stick to blood vessels, which is really important for people with Leukocyte Adhesion Deficiency-III, a condition that makes it hard for their bodies to stop bleeding and fight infections.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10902042 on NIH RePORTER |
What this research studies
This research investigates the role of kindlin-3 in activating integrins, which are crucial for the adhesion of blood cells like platelets and leukocytes to blood vessels. It focuses on patients with Leukocyte Adhesion Deficiency-III, a condition caused by mutations in the FERMT3 gene, leading to severe bleeding and infections. The research employs advanced techniques such as flow cytometry and superresolution microscopy to study how kindlin-3 functions in blood cells. By using a specially designed mouse model, researchers aim to uncover the mechanisms behind integrin activation and its implications for treating related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Leukocyte Adhesion Deficiency-III or related conditions affecting blood cell adhesion.
Not a fit: Patients without mutations in the FERMT3 gene or those not experiencing issues with blood cell adhesion may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from severe bleeding and bacterial infections due to integrin activation issues.
How similar studies have performed: Previous research has shown promising results in understanding integrin activation mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Ley, Klaus F. — University of California, San Diego
- Study coordinator: Ley, Klaus F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.