Understanding how kidney cysts develop in a genetic kidney disease
Official title: Role of complement in injury-induced cystogenesis among carriers of a single ADPKD gene defect
Funded at Birmingham VA Medical Center · NIH-11034083 · Data updated 2026-11-12
This study is looking at how a part of the immune system affects the growth of kidney cysts in people with a genetic condition called ADPKD, so we can find ways to spot those who might face more serious kidney problems and help them sooner.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Birmingham VA Medical Center NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01BX006266-02 |
| Project ID | NIH-11034083 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adults diagnosed with autosomal dominant polycystic kidney disease.
✕Less likely to help
Patients without a diagnosis of autosomal dominant polycystic kidney disease or those with other unrelated kidney conditions may not benefit from this research.
What this research studies
This research investigates the role of the complement system in the formation of kidney cysts in patients with a genetic condition known as autosomal dominant polycystic kidney disease (ADPKD). By utilizing advanced imaging techniques and a new animal model, the study aims to analyze the growth patterns of individual cysts, which can vary significantly over time. The goal is to identify biomarkers that can predict which patients, including children, are at higher risk for severe kidney issues, allowing for earlier and more tailored interventions.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for identifying high-risk patients with ADPKD, potentially preventing severe kidney damage.
How similar studies have gone: While the approach of using individual cyst growth patterns as biomarkers is innovative, similar studies have shown promise in understanding kidney diseases, suggesting potential for success.
Where this research is happening
-
Birmingham VA Medical Center
Birmingham, United States Active
Researchers
- Principal investigator: Mrug, Michal — Birmingham VA Medical Center
- Study coordinator: Mrug, Michal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.