Understanding how iron-sulfur proteins help control cellular functions and respond to stress
Official title: Structures and Mechanisms of Iron-Sulfur Proteins in Redox Control and Stress Response
Funded at University of Nebraska Lincoln · NIH-11137228 · Data updated 2026-11-12
This study looks at how certain proteins help keep our cells healthy and respond to stress, which could be important for people with conditions like cancer and diabetes, and aims to find out how these proteins work so we can better understand and treat these diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project start | September 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $65,848 |
| NIH project number | 3R35GM138157-05S1 |
| Project ID | NIH-11137228 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to cellular stress responses, such as cancer or diabetes.
✕Less likely to help
Patients with conditions unrelated to cellular redox processes or those not experiencing stress-related cellular dysfunction may not benefit from this research.
What this research studies
This research investigates the role of iron-sulfur (Fe-S) proteins in maintaining cellular health and responding to stress. By examining how these proteins sense redox changes and regulate gene expression, the study aims to uncover mechanisms that are crucial for cell survival in various conditions, including cancer and diabetes. The research employs biochemical and molecular biology techniques to explore the assembly, transfer, and repair of Fe-S clusters, as well as their interactions with other cellular components. Patients may benefit from insights gained into how these proteins function in disease contexts.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases like cancer and diabetes by targeting the mechanisms of redox control.
How similar studies have gone: Other research has shown promising results in understanding the roles of iron-sulfur proteins in cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Nebraska Lincoln
Lincoln, United States Active
Researchers
- Principal investigator: Zhang, Limei — University of Nebraska Lincoln
- Study coordinator: Zhang, Limei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.