Understanding how iron-sulfur proteins help control cellular functions and respond to stress
Structures and Mechanisms of Iron-Sulfur Proteins in Redox Control and Stress Response
['FUNDING_OTHER'] · UNIVERSITY OF NEBRASKA LINCOLN · NIH-10885089
This study looks at how certain proteins help keep our cells healthy and handle stress, which could lead to better understanding and treatments for conditions like cancer, diabetes, and infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA LINCOLN (nih funded) |
| Locations | 1 site (LINCOLN, UNITED STATES) |
| Trial ID | NIH-10885089 on ClinicalTrials.gov |
What this research studies
This research investigates the role of iron-sulfur (Fe-S) proteins in maintaining cellular health and responding to stress. It focuses on how these proteins sense redox changes, regulate gene expression, and manage the assembly and repair of Fe-S clusters. By studying these mechanisms, the research aims to uncover how Fe-S proteins contribute to diseases like cancer and diabetes, as well as bacterial infections. Patients may benefit from insights gained into how these proteins affect cell survival and function.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to cellular stress responses, such as cancer patients or those with metabolic disorders.
Not a fit: Patients with conditions unrelated to cellular function or redox control may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to cellular dysfunction, such as cancer and diabetes.
How similar studies have performed: Other research has shown promising results in understanding the roles of iron-sulfur proteins in cellular processes, indicating that this area of study has potential for significant breakthroughs.
Where this research is happening
LINCOLN, UNITED STATES
- UNIVERSITY OF NEBRASKA LINCOLN — LINCOLN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, LIMEI — UNIVERSITY OF NEBRASKA LINCOLN
- Study coordinator: ZHANG, LIMEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections, Cancers