Understanding how iron-sulfur clusters help enzymes work
Official title: Spectroscopic Characterization of Enzymatic Intermediates with FeS Clusters
Funded at University of California at Davis · NIH-11070728 · Data updated 2026-11-12
This study is looking at how certain tiny structures in enzymes help them work, which could lead to new medicines and treatments for patients by mimicking these natural processes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | December 6, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $73,828 |
| NIH project number | 1F32GM157846-01 |
| Project ID | NIH-11070728 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions related to enzyme deficiencies or metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to enzymatic functions or those not affected by biochemical pathways involving iron-sulfur clusters may not receive any benefit from this research.
What this research studies
This research investigates the role of iron-sulfur clusters in enzymes, which are crucial for various biochemical reactions in living organisms. By using advanced spectroscopic techniques, the study aims to uncover the mechanisms behind these enzymes' functions and how they catalyze important chemical transformations. Patients may benefit from insights gained in this research, as it could lead to the development of new drugs and catalysts that mimic these natural processes. The research focuses on specific enzymes involved in the biosynthesis of vital compounds, providing a detailed understanding of their action.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapeutic drugs and biocatalysts that improve treatment options for various diseases.
How similar studies have gone: Previous research has shown success in understanding enzyme mechanisms through similar spectroscopic techniques, indicating a promising approach for this study.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Shiau, Angela — University of California at Davis
- Study coordinator: Shiau, Angela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.